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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HGS
All Species:
18.48
Human Site:
S246
Identified Species:
36.97
UniProt:
O14964
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14964
NP_004703.1
777
86192
S246
T
S
P
L
S
Q
Q
S
Q
L
P
P
K
R
D
Chimpanzee
Pan troglodytes
XP_511742
777
85768
Q246
S
P
L
S
Q
Q
S
Q
L
P
P
K
R
D
E
Rhesus Macaque
Macaca mulatta
XP_001111673
777
86015
S246
T
S
P
L
S
Q
Q
S
Q
L
P
P
K
R
D
Dog
Lupus familis
XP_540486
782
86005
P250
S
Q
Q
S
Q
L
P
P
K
R
D
E
T
A
L
Cat
Felis silvestris
Mouse
Mus musculus
Q99LI8
775
85996
S246
T
S
P
L
S
Q
Q
S
Q
L
P
P
K
R
D
Rat
Rattus norvegicus
Q9JJ50
776
86228
S246
T
S
P
L
S
Q
Q
S
Q
L
P
P
K
R
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001083588
751
84100
A246
T
S
P
L
S
Q
Q
A
Q
T
P
P
K
R
D
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q960X8
760
85396
N244
E
L
P
A
E
Y
L
N
S
T
L
A
Q
Q
V
Honey Bee
Apis mellifera
XP_393989
830
92147
Q245
N
S
S
L
A
Q
Q
Q
Q
V
P
P
R
K
T
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_783582
784
87687
S243
N
S
P
L
A
Q
Q
S
Q
M
P
P
Q
R
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P40343
622
70927
F148
L
I
S
R
G
I
K
F
P
E
K
L
T
L
S
Red Bread Mold
Neurospora crassa
Q7RZJ2
724
79729
S243
G
S
D
R
K
H
H
S
S
S
R
H
H
H
H
Conservation
Percent
Protein Identity:
100
95.5
98.8
92.3
N.A.
93.3
93.4
N.A.
N.A.
N.A.
80
N.A.
N.A.
41.7
47.7
N.A.
49.4
Protein Similarity:
100
96.6
98.9
94.2
N.A.
95.6
95.6
N.A.
N.A.
N.A.
87.5
N.A.
N.A.
55.7
60.9
N.A.
61.3
P-Site Identity:
100
13.3
100
0
N.A.
100
100
N.A.
N.A.
N.A.
86.6
N.A.
N.A.
6.6
46.6
N.A.
66.6
P-Site Similarity:
100
33.3
100
13.3
N.A.
100
100
N.A.
N.A.
N.A.
93.3
N.A.
N.A.
26.6
73.3
N.A.
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
21.2
24.9
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
40.6
41
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
13.3
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
6.6
13.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
9
17
0
0
9
0
0
0
9
0
9
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
9
0
0
0
0
0
0
0
9
0
0
9
42
% D
% Glu:
9
0
0
0
9
0
0
0
0
9
0
9
0
0
9
% E
% Phe:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% F
% Gly:
9
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
9
9
0
0
0
0
9
9
9
9
% H
% Ile:
0
9
0
0
0
9
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
9
0
9
0
9
0
9
9
42
9
0
% K
% Leu:
9
9
9
59
0
9
9
0
9
34
9
9
0
9
9
% L
% Met:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% M
% Asn:
17
0
0
0
0
0
0
9
0
0
0
0
0
0
9
% N
% Pro:
0
9
59
0
0
0
9
9
9
9
67
59
0
0
0
% P
% Gln:
0
9
9
0
17
67
59
17
59
0
0
0
17
9
0
% Q
% Arg:
0
0
0
17
0
0
0
0
0
9
9
0
17
50
0
% R
% Ser:
17
67
17
17
42
0
9
50
17
9
0
0
0
0
9
% S
% Thr:
42
0
0
0
0
0
0
0
0
17
0
0
17
0
9
% T
% Val:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _